ELECTROCHEMICAL DETERMINATION OF IBUPROFEN

Two simple and accurate electrochemical methods for the determination of ibuprofen (GAS 15687-27-1) as a bulk drug and as an active compound in pharmaceutical formulations are presented. For the potentiometric determination of ibuprofen sodium hydroxide and triethanolamine were u sed as titrants. The influence of different solvents, such as water, m ethanol, acetonitrile, dimethyl sulfoxide and N,N-dimethylformamide, o n the conductometric titrations was investigated. The same titrants as in the potentiometric titrations were used. The methods are accurate and results are reproducible in quantities ranging from 1 to 10 mg of ibuprofen in analysed pharmaceutical dosage forms. The relative standa rd deviation (n = 10) varies over the range 0.38-1.63 %.