A. Yesilkaya et A. Yegin, INHIBITION OF HUMAN ERYTHROCYTE (NA-K+)ATPASE BY ORGANIC HYDROPEROXIDES AND PROTECTION BY ASCORBIC-ACID AND BUTYLATED HYDROXYTOLUENE(), General pharmacology, 30(4), 1998, pp. 495-498
1. The in vitro effects of cumene hydroperoxide and t-butyl hydroperox
ide on intact human erythrocyte membrane (Na+-K+)ATPase activities hav
e been studied. 2. (Na+-K+)ATPase activities on erythrocyte membranes
decreased in agreement with the results of chemiluminescence experimen
ts. 3. Our results demonstrated that the organic hydroperoxides inhibi
t the activity of (Na+-K+) ATPase enzyme and that the antioxidants use
d prevent this inhibition. (C) 1998 Elsevier Science Inc.