INHIBITION OF HUMAN ERYTHROCYTE (NA-K+)ATPASE BY ORGANIC HYDROPEROXIDES AND PROTECTION BY ASCORBIC-ACID AND BUTYLATED HYDROXYTOLUENE()

Authors
YESILKAYA A YEGIN A
Citation
A. Yesilkaya et A. Yegin, INHIBITION OF HUMAN ERYTHROCYTE (NA-K+)ATPASE BY ORGANIC HYDROPEROXIDES AND PROTECTION BY ASCORBIC-ACID AND BUTYLATED HYDROXYTOLUENE(), General pharmacology, 30(4), 1998, pp. 495-498
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
General pharmacology → ACNP
ISSN journal
03063623
Volume
30
Issue
4
Year of publication
1998
Pages
495 - 498
Database
ISI
SICI code
0306-3623(1998)30:4<495:IOHE(B>2.0.ZU;2-J
Abstract
1. The in vitro effects of cumene hydroperoxide and t-butyl hydroperox ide on intact human erythrocyte membrane (Na+-K+)ATPase activities hav e been studied. 2. (Na+-K+)ATPase activities on erythrocyte membranes decreased in agreement with the results of chemiluminescence experimen ts. 3. Our results demonstrated that the organic hydroperoxides inhibi t the activity of (Na+-K+) ATPase enzyme and that the antioxidants use d prevent this inhibition. (C) 1998 Elsevier Science Inc.