EFFECTS OF INTRATHECALLY ADMINISTERED AMINOGLYCOSIDE ANTIBIOTICS, CALCIUM-CHANNEL BLOCKERS, NICKEL AND CALCIUM ON ACETIC ACID-INDUCED WRITHING TEST IN MICE

1. Antinociceptive effects of intrathecally administered aminoglycosid e antibiotics, cal cium-channel blockers, nickel and calcium ions on t he acetic acid-induced writhing test in mice were examined, 2. Neomyci n (0.5-20.0 mu g/mouse) gentamicin (5-40 mu g/mouse), nicardipine, dil tiazem and verapamil (0.5-80.0 mu g/mouse) and calcium ions (0.02-1.0 mu mol/mouse) exerted a dose-dependent antinociceptive activity on the acetic acid-induced writhing test. Nickel ions ( 2.5, 5.0 and 10.0 mu mol/mouse) were found ineffective in this test. 3. These results sugg est that N- and L-type, but not T-type, voltage dependent calcium chan nels are implicated in the spinal processing of nociceptive informatio n. (C) 1998 Elsevier Science Inc.