Botryomycosis is an uncommon bacterial disease characterized by the mi
croscopic formation of eosinophilic granules that resemble those of in
fection by Actinomyces species, The diagnosis of botryomycosis can be
made when microscopic inspection and culture of the granules reveal gr
ampositive cocci or gram-negative bacilli. Botryomycosis is caused by
common bacterial pathogens including Staphylococcus aureus, Escherichi
a coil, and Pseudomonas aeruginosa, yet the host and microbial factors
that contribute to the pathobiology remain unknown. Pulmonary botryom
ycosis can resemble actinomycosis, tuberculosis, or invasive carcinoma
by causing a mass lesion with constitutional symptoms. Radiographical
ly, it invades bone and disrupts tissue planes. Successful treatment o
ften requires a combination of both surgical debridement and long-term
antimicrobial therapy, We report a case of primary pulmonary botryomy
cosis and review the literature on this unusual infectious process.