This study evaluates the variations in the acoustic properties of the
human femur at ten evenly spaced locations along its length, as well a
s differences that exist within given transverse sections. Six pairs o
f human femora, three male and three female, were sectioned, ground, a
nd polished, and scanned with a microprocessor-driven scanning acousti
c microscope. Images with a resolution of approximately 140 mu m were
used to calculate the average acoustic impedances for each transverse
cross section and each quadrant within a cross section. The mean acous
tic impedance for all the cross sections was 7.69 +/- 0.18 Mrayls. Var
iations were observed among the cross sections, and the central sectio
ns (4-7) had values that were statistically greater than the other mor
e distal and proximal sections. Within the cross sections, the posteri
or quadrant had a lower average acoustic impedance compared to the oth
er quadrants and this was statistically significant (Tukey's multiple
comparison test). The cross sections were further analyzed to determin
e several geometric parameters including the principal moments of iner
tia, polar moment of inertia, and the biomechanical shape index. The p
roduct of the acoustic impedance and the maximum moment of inertia pro
vided a result that attempted to account for the acoustic property var
iation and the change in shape at the different section locations.