SPECIFIC ABSORPTION PARAMETERS FOR URANIUM OCTOXIDE AND DIOXIDE APPLICABLE TO THE ICRP PUBLICATION-66 RESPIRATORY-TRACT MODEL

Literature data from in vivo chest measurements and urinary excretion rates of individuals exposed to U3O8 and UO2 were used to compare the results predicted by different models with empirical observations in h umans. As a result the use of the respiratory tract model proposed in ICRP Publication 66 with its default absorption parameters underestima tes urinary excretion of inhaled U3O8 and UO2. The new respiratory tra ct model also overpredicts the Fecal/Urine activity ratio, independent ly of the systemic model. For U3O8 and UO2 the choice of systemic mode l has very little influence on the predicted urinary excretion of inha led compounds. On the other way, the choice of the respiratory tract m odel does influence the predicted urinary excretion significantly. In this work specific absorption parameters for U3O8 and UO2 were derived to be used in the respiratory tract model proposed in ICRP Publicatio n 66. The predicted biokinetics of these compounds were compared with those derived for Type M and Type S compounds of uranium.