FIBRILLARY GLOMERULONEPHRITIS IN CASTLEMANS-DISEASE

Castleman's disease is an uncommon lymph node disorder which can be as sociated with renal disease. In this report we describe a patient with fever, weight loss, anorexia, increase in inflammatory proteins, anem ia and nephrotic syndrome, Castleman's disease, plasma cell type, was diagnosed by histologic analysis after surgical excision of a pelvic l ymph node, The disease was considered localized, since further investi gations did not show any other pathologic mass. After resection of the pelvic lymphoid mass, clinical remission of systemic symptoms and lab oratory abnormalities was observed., with the exception of the nephrot ic syndrome, Renal biopsy was performed and showed a pattern compatibl e with fibrillary glomerulonephritis. Progressive decline in renal fun ction was observed, despite immunosuppressive therapy.