SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW 4-ALKOXY, 4-AMINOALKYL AND 4-ALKYLTHIOQUINOLINE DERIVATIVES

Authors
KAYIRERE MG MAHAMOUD A CHEVALIER J SOYFER JC CREMIEUX A BARBE J
Citation
Mg. Kayirere et al., SYNTHESIS AND ANTIBACTERIAL ACTIVITY OF NEW 4-ALKOXY, 4-AMINOALKYL AND 4-ALKYLTHIOQUINOLINE DERIVATIVES, European journal of medicinal chemistry, 33(1), 1998, pp. 55-63
Citations number
9
Categorie Soggetti
Chemistry Medicinal
Journal title
European journal of medicinal chemistry → ACNP
ISSN journal
02235234
Volume
33
Issue
1
Year of publication
1998
Pages
55 - 63
Database
ISI
SICI code
0223-5234(1998)33:1<55:SAAAON>2.0.ZU;2-C
Abstract
4-Alkoxy-8-methyl-7-nitroquinolines, 4-alkylamino-8-methyl-7-nitroquin olines, 4-alkoxy-2,8-dimethylquinolines, 4-alkylthioquinolines were pr epared from 8-methyl-7-nitro-4-quinolone, 8-methyl-7-nitro-4-chloro-qu inoline, 2,8-dimethyl-4-quinolone and 4-hydroxyquinoline used as start ing material. Compounds were characterized from H-1 and C-13 NMR spect ra. These drugs were tested against selected gram-, gram+ and mycobact eria strains. A promising activity was observed against Mycobacterium smegmatis. (C) Elsevier, Paris.