ISOLATED PLEURAL EFFUSION WITH HEMATOPOIETIC-CELLS OF MIXED LINEAGE IN A PATIENT RECEIVING GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER HIGH-DOSE CHEMOTHERAPY

A 43-yr-old woman with recently diagnosed breast carcinoma presented w ith a right pleural effusion after a cycle of adjuvant, high-dose chem otherapy supported by peripheral blood progenitor cells (PBPC) and gra nulocyte-colony-stimulating facto (G-CSF, Filgrastim). Cytologic exami nation of the pleural aspirate yielded highly cellular material compos ed predominantly of cells of myeloid and macrophage/monocytic lineages . Despite clinical concern of a malignant effusion, the combination of cytologic and immunophenotypic examination yielded the correct diagno sis of a nonneoplastic effusion related to underlying pleural inflamma tion and possibly the administration of G-CSF. (C) 1998 Wiley-Liss, In c.