ISOLATED PLEURAL EFFUSION WITH HEMATOPOIETIC-CELLS OF MIXED LINEAGE IN A PATIENT RECEIVING GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER HIGH-DOSE CHEMOTHERAPY
Ia. Busmanis et al., ISOLATED PLEURAL EFFUSION WITH HEMATOPOIETIC-CELLS OF MIXED LINEAGE IN A PATIENT RECEIVING GRANULOCYTE-COLONY-STIMULATING FACTOR AFTER HIGH-DOSE CHEMOTHERAPY, Diagnostic cytopathology, 18(3), 1998, pp. 204-207
A 43-yr-old woman with recently diagnosed breast carcinoma presented w
ith a right pleural effusion after a cycle of adjuvant, high-dose chem
otherapy supported by peripheral blood progenitor cells (PBPC) and gra
nulocyte-colony-stimulating facto (G-CSF, Filgrastim). Cytologic exami
nation of the pleural aspirate yielded highly cellular material compos
ed predominantly of cells of myeloid and macrophage/monocytic lineages
. Despite clinical concern of a malignant effusion, the combination of
cytologic and immunophenotypic examination yielded the correct diagno
sis of a nonneoplastic effusion related to underlying pleural inflamma
tion and possibly the administration of G-CSF. (C) 1998 Wiley-Liss, In
c.