NOVEL ANTIMALARIAL GUAIANE-TYPE SESQUITERPENOIDS FROM NARDOSTACHYS CHINENSIS ROOTS

Authors
TAKAYA Y KURUMADA K TAKEUJI Y KIM HS SHIBATA Y IKEMOTO N WATAYA Y OSHIMA Y
Citation
Y. Takaya et al., NOVEL ANTIMALARIAL GUAIANE-TYPE SESQUITERPENOIDS FROM NARDOSTACHYS CHINENSIS ROOTS, Tetrahedron letters, 39(11), 1998, pp. 1361-1364
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
11
Year of publication
1998
Pages
1361 - 1364
Database
ISI
SICI code
0040-4039(1998)39:11<1361:NAGSFN>2.0.ZU;2-H
Abstract
Three guaiane-type sesquiterpenoids, nardoperoxide (1a), isonardoperox ide (2a) and nardoxide (3), were isolated from Nardostachys chinensis roots. Their structures were elucidated by spectral means. Among them, two endoperoxides, nardoperoxide (1a) and isonardoperoxide (2a), show ed strong antimalarial activity against Plasmodium falciparum malaria (EC50 1.5 x 10(-6) and 6.0 x 10(-7) M, respectively). (C) 1998 Elsevie r Science Ltd. All rights reserved.