POLYOXYPEPTIN ISOLATED FROM STREPTOMYCES - A BIOACTIVE CYCLIC DEPSIPEPTIDE CONTAINING THE NOVEL AMINO-ACID 3-HYDROXY-3-METHYLPROLINE

Authors
UMEZAWA K NAKAZAWA K UEMURA T IKEDA Y KONDO S NAGANAWA H KINOSHITA N HASHIZUME H HAMADA M TAKEUCHI T OHBA S
Citation
K. Umezawa et al., POLYOXYPEPTIN ISOLATED FROM STREPTOMYCES - A BIOACTIVE CYCLIC DEPSIPEPTIDE CONTAINING THE NOVEL AMINO-ACID 3-HYDROXY-3-METHYLPROLINE, Tetrahedron letters, 39(11), 1998, pp. 1389-1392
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
11
Year of publication
1998
Pages
1389 - 1392
Database
ISI
SICI code
0040-4039(1998)39:11<1389:PIFS-A>2.0.ZU;2-X
Abstract
Polyoxypeptin, a potent inducer of apoptosis in human pancreatic carci noma cells, was isolated from an ethyl acetate extract of a Streptomyc es culture broth. Structural determination by 2D-NMR and X-ray crystal lographic analysis revealed that it is a novel cyclic hexadepsipeptide containing five hydroxylated amino acids. The unusual and hitherto un reported amino acid 3-hydroxy-3-methylproline was one of them. (C) 199 8 Elsevier Science Ltd. All rights reserved.