A MOUSE MODEL OF BORRELIA MENINGITIS AFTER INTRADERMAL INJECTION

Authors
GARCIAMONCO JC MILLER NS BACKENSON PB ANDA P BENACH JL
Citation
Jc. Garciamonco et al., A MOUSE MODEL OF BORRELIA MENINGITIS AFTER INTRADERMAL INJECTION, The Journal of infectious diseases, 175(5), 1997, pp. 1243-1245
Citations number
11
Categorie Soggetti
Infectious Diseases
Journal title
The Journal of infectious diseases → ACNP
ISSN journal
00221899
Volume
175
Issue
5
Year of publication
1997
Pages
1243 - 1245
Database
ISI
SICI code
0022-1899(1997)175:5<1243:AMMOBM>2.0.ZU;2-B
Abstract
Both young and adult C3H/HeN mice developed meningitis within 3 weeks of intradermal inoculation with a newly identified uncultivable Borrel ia species, an agent of human relapsing fever, Meningoencephalitis wit h perivascular infiltrates and plexitis developed at similar to 25 day s after inoculation, Infiltrates were composed of B and plasma cells a nd monocytes, This model recreated the meningitis associated with spir ochetal infections through an intradermal route of infection.