LONG-LASTING ANTIBODIES DETECTED BY A TRANS-SIALIDASE INHIBITION ASSAY OF SERA FROM PARASITE-FREE, SEROLOGICALLY CURED CHAGASIC PATIENTS

Authors
LEGUIZAMON MS RUSSOMANDO G LUQUETTI A RASSI A ALMIRON M GONZALEZCAPPA SM FRASCH ACC CAMPETELLA O
Citation
Ms. Leguizamon et al., LONG-LASTING ANTIBODIES DETECTED BY A TRANS-SIALIDASE INHIBITION ASSAY OF SERA FROM PARASITE-FREE, SEROLOGICALLY CURED CHAGASIC PATIENTS, The Journal of infectious diseases, 175(5), 1997, pp. 1272-1275
Citations number
11
Categorie Soggetti
Infectious Diseases
Journal title
The Journal of infectious diseases → ACNP
ISSN journal
00221899
Volume
175
Issue
5
Year of publication
1997
Pages
1272 - 1275
Database
ISI
SICI code
0022-1899(1997)175:5<1272:LADBAT>2.0.ZU;2-J
Abstract
A test based on the inhibition by antibodies of the trans-sialidase wa s used to analyze infection by Trypanosoma cruzi, the agent of Chagas' disease. Sera collected during the longitudinal followup of benznidaz ole-treated acutely and congenitally infected patients became negative for T. cruzi as determined by tests presently used to assess cure; ho wever, the sera remained positive for T. cruzi by the trans-sialidase inhibition assay (TIA) up to 14 pears after treatment, Therefore, TIA is a highly sensitive marker for previous T. cruzi infection.