POLYMER-SUPPORTED CATALYSTS FOR EFFICIENT ON-COLUMN PREPARATION OF 2-DEOXY-2-[F-18]FLUORO-D-GLUCOSE

Several kinds of polymer-supported quaternary salts, such as dimethyla minopyridinium or tributylphosphonium salts, have been examined for th e on-column preparation of [F-18]FDG. Factors affecting [F-18]fluoride trapping efficiency and [F-18]fluorination yield have been optimized. [F-18]Fluoride was practically, quantitatively trapped from flowing w ater and the subsequent F-18-substitution was carried out on-column wi th a radiochemical yield of over 70% (EOB). The improvement in the [F- 18]fluorination yield was achieved by introducing a spacer alkene chai n between the supporting resin molecule and the catalytic site. A resi n with higher cross-linkage and lower content of catalytic sites was s hown to be useful for preventing column plugging. (C) 1998 Elsevier Sc ience Ltd. All rights reserved.