Purpose, To evaluate the predictability of the depth of stromal pocket
s made in the posterior cornea for the excision of anterior or posteri
or lamellar corneal buttons with a planned thickness. Methods, Stromal
corneal pocket dissections were created in human eye bank eyes by mak
ing a peripheral arcuate keratotomy incision at 60, 80, or 95% of cent
ral pachymetry and creating a pocket from the bottom of the incision a
cross the cornea. Pocket depth was measured by pachymetry immediately
after surgery and by light microscopy. Results. Mean achieved central
pocket depth differed by 0.03+/-0.03 mm from the intended depth. Varia
tion in depth across the pocket decreased from 0.07+/-0.02 mm for pock
ets made at 60% of the intended depth to 0.05+/-0.01 mm for pockets ma
de at 80(ro depth, and 0.04+/-0.02 mm for pockets made at 95% depth (p
< 0.01). Pachymetric and histological measurements of relative pocket
depth averaged 64+/-9% and 73+/-7%, respectively, for pockets made at
60% of the intended depth, 82+/-7% and 86+/-3% for pockets made at 80
% depth, and 91+/-7% and 92+/-3% for pockets made at 95% depth. The di
fference between pachymetric and histological relative pocket depth me
asurements decreased with deeper pocket depth (p < 0.01). Conclusions.
In the posterior cornea, stromal pockets can be created to within 30
mu m from the intended depth. Variation in depth throughout the pocket
decreases with deeper pocket depth. Pachymetry is a reliable method t
o check the achieved pocket depth during surgery, the accuracy of pach
ymetry readings improves with deeper pocket depth.