SEROTONIN TRANSPORTER (5-HTT) GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH SUSCEPTIBILITY TO MOOD-DISORDERS

Citation
Mr. Hoehe et al., SEROTONIN TRANSPORTER (5-HTT) GENE POLYMORPHISMS ARE NOT ASSOCIATED WITH SUSCEPTIBILITY TO MOOD-DISORDERS, American journal of medical genetics, 81(1), 1998, pp. 1-3
Citations number
13
Categorie Soggetti
Genetics & Heredity
ISSN journal
01487299
Volume
81
Issue
1
Year of publication
1998
Pages
1 - 3
Database
ISI
SICI code
0148-7299(1998)81:1<1:ST(GPA>2.0.ZU;2-3
Abstract
In a population-based association study, we tested the hypothesis that allelic variants of the human serotonin transporter (5-HTT) gene conf er susceptibility to mood disorders, Both a biallelic repeat polymorph ism in the 5' promotor region that differentially modulates gene expre ssion and a second intron variable-number-tandem-repeat (VNTR) marker were genotyped in 294 controls and 115 patients with mood disorders, S ubjects were of West European descent and included 36 patients with ma jor depressive disorder (MDD) and 79 patients with bipolar I disorder (BD), No significant differences in genotype or allele frequencies mer e found at either locus between controls and combined patients, nor be tween controls and MDD or BD patients separately. Thus, our data do no t support the association between depressive disorder and a nine-repea t allelic variant of the 5-HTT VNTR marker recently reported by Ogilvi e et al. (Lancet 347:731-733, 1996), More importantly, no association between alleles conveying functional differences in 5-HTT gene express ion and MDD or BD could be found. Taken together, our data suggest tha t the 5-HTT gene is not commonly involved in the susceptibility to moo d disorders, (C) 1998 Wiley-Liss, Inc.