ONE-POT REDUCTION OF CARBOXYLIC-ACIDS VIA O-ACYLISOUREAS

Authors
HERBERT JM HEWSON AT PEACE JE
Citation
Jm. Herbert et al., ONE-POT REDUCTION OF CARBOXYLIC-ACIDS VIA O-ACYLISOUREAS, Synthetic communications, 28(5), 1998, pp. 823-832
Citations number
15
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synthetic communications → ACNP
ISSN journal
00397911
Volume
28
Issue
5
Year of publication
1998
Pages
823 - 832
Database
ISI
SICI code
0039-7911(1998)28:5<823:OROCVO>2.0.ZU;2-6
Abstract
A simple one-pot reduction of aliphatic carboxylic acids to primary al cohols, by treatment with dicyclohexylcarbodiimide followed by lithium borohydride, is reported. The same methodology applied to aromatic ca rboxylic acids is shown to give a mixture of the alcohols with N-cyclo hexylcarboxamides.