A SEROTONIN-4 RECEPTOR-LIKE PSEUDOGENE IN HUMANS

During a search for new G-protein-linked receptors for dopamine and se rotonin, we found a serotonin-4 receptor-like pseudogene. This recepto r-like pseudogene is intronless, contains an in-frame stop codon follo wing transmembrane-3, and has two one-nucleotide insertions between tr ansmembrane-5 and -6 regions which alter the reading frame. The predic ted amino acid sequence of the human pseudogene is about 35% identical with that of the rat serotonin-4 receptor. (C) 1998 Elsevier Science B.V.