EXPRESSION OF HEXOKINASE MESSENGER-RNA IN HUMAN HIPPOCAMPUS

The expression of hexokinase messenger RNA was evaluated in human hipp ocampus using in situ hybridization technique. The message showed an u neven distribution with high levels present in the granular cell layer of the dentate gyrus and CA3 region. The detection of specific transc ripts was also observed in the lateral geniculate nucleus, the dentate polymorphic cell layer and the parahippocampal gyrus. The data sugges t that, in the hippocampus, the expression of hexokinase is higher in neurons than in glial cells and that the rate of glucose metabolism ma y display considerable variations in the different subregions of this area. (C) 1998 Elsevier Science B.V.