INHIBITION OF LYSOPHOSPHATIDIC ACID-INDUCED NEURITE RETRACTION AND CELL ROUNDING BY SR 57746A

Authors
MAGAZIN M SCHILTZ P ZACHAYUS JL CAVROIS E CAPUT D FERRARA P
Citation
M. Magazin et al., INHIBITION OF LYSOPHOSPHATIDIC ACID-INDUCED NEURITE RETRACTION AND CELL ROUNDING BY SR 57746A, Molecular brain research, 53(1-2), 1998, pp. 301-306
Citations number
26
Categorie Soggetti
Neurosciences
Journal title
Molecular brain research → ACNP
ISSN journal
0169328X
Volume
53
Issue
1-2
Year of publication
1998
Pages
301 - 306
Database
ISI
SICI code
0169-328X(1998)53:1-2<301:IOLANR>2.0.ZU;2-3
Abstract
Rapid neurite retraction and transient rounding of serum-starved NG108 -15 and PC12 cells by lysophosphatidic acid (LPA) is retarded and redu ced by pre-incubation of the cells with the small non-peptidic molecul e, SR 57746A, which exhibits neurotrophic properties. The compound als o antagonizes the redistribution of filamentous actin by LPA in both c ell types. We hypothesize that the SR57746A attenuation of LPA-induced effects may account for at least some of the neuroprotective properti es of this molecule. (C) 1998 Elsevier Science B.V.