ANTISENSE OLIGONUCLEOTIDES AND MYOTONIN GENE-EXPRESSION IN C2 MOUSE CELLS

Authors
MELONE MAB GALDERISI U IACOMINO G CIPOLLARO M DIBERNARDO G COTRUFO R PELUSO G CASCINO A
Citation
Mab. Melone et al., ANTISENSE OLIGONUCLEOTIDES AND MYOTONIN GENE-EXPRESSION IN C2 MOUSE CELLS, ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 8(1), 1998, pp. 25-33
Citations number
30
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Biothechnology & Applied Migrobiology
Journal title
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT → ACNP
ISSN journal
10872906
Volume
8
Issue
1
Year of publication
1998
Pages
25 - 33
Database
ISI
SICI code
1087-2906(1998)8:1<25:AOAMGI>2.0.ZU;2-G
Abstract
By describing the behavior of myotonin mRNA levels, from the quiescent to the differentiated state in C2 mouse myoblasts, we produced eviden ce bearing on the role of myotonin gene product in the control of cell growth and differentiation. To study the role of myotonin in myotonic dystrophy (DM) pathogenesis, we developed a suitable cellular model w here myotonin gene expression was modulated by phosphorothioate antise nse oligonucleotides in C2 cultured cells. Furthermore, an isoform of the gene product, similar to that described in humans and not yet desc ribed in the mouse, was found.