IMPROVING THE EFFICIENCY OF ANTISENSE AND EGS METHODS

Authors
SALAVATI R ALTMAN S
Citation
R. Salavati et S. Altman, IMPROVING THE EFFICIENCY OF ANTISENSE AND EGS METHODS, ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT, 8(1), 1998, pp. 63-65
Citations number
9
Categorie Soggetti
Biology,"Medicine, Research & Experimental","Biothechnology & Applied Migrobiology
Journal title
ANTISENSE & NUCLEIC ACID DRUG DEVELOPMENT → ACNP
ISSN journal
10872906
Volume
8
Issue
1
Year of publication
1998
Pages
63 - 65
Database
ISI
SICI code
1087-2906(1998)8:1<63:ITEOAA>2.0.ZU;2-3
Abstract
Hammerhead ribozymes and stable stem loop structures function as inhib itors of 3'-5'-exonuclease degradation of external guide sequences (EG Ss) when covalently linked to the 3'-end of EGS RNAs. This observation may be of use in improving the efficiency of gene inactivation techni ques that use single-stranded RNA (e.g., antisense RNA, EGS RNA) in vi vo.