MANAGEMENT OF MALIGNANT OVARIAN-TUMORS IN YOUNG-WOMEN - 21 NULLIPAROUS CASES

To evaluate the management of malignant ovarian tumors in young women who wish to maintain fertility, we retrospectively reviewed ovarian ma lignancies in 21 young women who were both nulliparous and under 40 ye ars of age. With stage 1a disease, all 9 patients were treated with co nservative surgical therapies, and all of them are still alive, irresp ective of histological type. With stage 1c disease, 5 (83%) of 6 patie nts were treated with conservative surgical therapies. Among them, 2 p atients with epithelial tumors, who were treated with conservative sur gical therapies and potent cis-diamminedichloroplatinum (CDDP)-based c ombined chemotherapies, are still alive. Furthermore, one of them had a successful pregnancy. On the other hand, 3 out of 4 patients with no nepithelial tumors were treated with conservative surgical therapies. However, 2 (67%) out of 3 died; both of them were treated with non-CDD P-based chemotherapy. In 6 patients with disease beyond stage 2, 3 (67 %) were treated with radical surgical therapies, but 2 (33%) were trea ted with conservative surgery and CDDP-based combined chemotherapy, on e of which was followed by a successful pregnancy in spite of nonepith elial tumor. As above, we could obtain some successful pregnancies in cases beyond stage 1c after conservative surgery by adding definite CD DP-based combined chemotherapy. However, we must carefully select the patients with nonepithelial tumors for conservative therapy by adding definite CDDP-based combined chemotherapy and inform them of the risks of therapy.