MONOVARIATE-ANALYSIS AND MULTIVARIATE-ANA LYSIS OF FACTORS PREDICTINGSURVIVAL IN HEPATOCELLULAR-CARCINOMA - A SERIES OF 122 PATIENTS

The files of 122 patients hospitalized for hepatocellular carcinoma (H CC) were reviewed retrospectively to study survival as a function of t reatment and different peri-therapeutic factors. Cirrhosis was certain or probable in 69 cases. Laparotomy was performed 77 times (13 explor atory, 64 excisions). Chemoembolization with Adriamycine was performed 18 times. Median survival was 11.6 months. The factors influencing su rvival in monovariate analysis were the Child-Pugh stage (p < 0.0001), the Okuda stage (p < 0.0001), ascites (p < 0.0001), a post-operative complication (p < 0.0001), gamma-glutamyltransferase level (p < 0.0037 ), tumor site (p < 0.004), albuminemia (p < 0.008), alkaline phosphata se concentration (p < 0.0087), number of tumors (p < 0.01), portal thr ombosis (p < 0.01) and alpha-foetoprotein level (p < 0.01). In multiva riate study, the Okuda stage (p < 0.001), age (p < 0.001) and portal t hrombosis (p < 0.037) remained significant. The Okuda 1 group was also considered in multivariate study, in which case only patient age and the possibility of therapeutic excision were significant factors. In o ur opinion, the Okuda classification, which is easy to establish, shou ld be adopted for pretherapeutic evaluation of patients with hepatocel lular carcinoma.