LATE-ONSET WARFARIN-INDUCED SKIN NECROSIS - CASE-REPORT AND REVIEW OFTHE LITERATURE

Warfarin-induced skin necrosis is a rare complication of therapy with warfarin or other coumarin derivatives, When it occurs it usually appe ars 3 to 6 days after initiation of therapy and almost always between days 1 and 10. We report a case of late-onset (16 days after initiatio n of therapy) warfarin-induced skin necrosis and review the literature on this rarely reported variant of warfarin-induced skin necrosis, Th e skin lesion in our patient was not associated with either deficiency of protein C or resistance to activated protein. (C) 1998 Wiley-Liss, Inc.