Dw. Essex et al., LATE-ONSET WARFARIN-INDUCED SKIN NECROSIS - CASE-REPORT AND REVIEW OFTHE LITERATURE, American journal of hematology, 57(3), 1998, pp. 233-237
Warfarin-induced skin necrosis is a rare complication of therapy with
warfarin or other coumarin derivatives, When it occurs it usually appe
ars 3 to 6 days after initiation of therapy and almost always between
days 1 and 10. We report a case of late-onset (16 days after initiatio
n of therapy) warfarin-induced skin necrosis and review the literature
on this rarely reported variant of warfarin-induced skin necrosis, Th
e skin lesion in our patient was not associated with either deficiency
of protein C or resistance to activated protein. (C) 1998 Wiley-Liss,
Inc.