TMC-49A, A NOVEL TRANSCRIPTIONAL UP-REGULATOR OF LOW-DENSITY-LIPOPROTEIN RECEPTOR, PRODUCED BY STREPTOMYCES SP. AS1345

Authors
KOGUCHI Y ASAI Y SUZUKI S NISHIO M YANAKA N OMORI K OHNUKI T KOMATSUBARA S
Citation
Y. Koguchi et al., TMC-49A, A NOVEL TRANSCRIPTIONAL UP-REGULATOR OF LOW-DENSITY-LIPOPROTEIN RECEPTOR, PRODUCED BY STREPTOMYCES SP. AS1345, Journal of antibiotics, 51(2), 1998, pp. 107-111
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
2
Year of publication
1998
Pages
107 - 111
Database
ISI
SICI code
0021-8820(1998)51:2<107:TANTUO>2.0.ZU;2-Y
Abstract
Microbial metabolites were screened for a transcriptional up-regulator of low density lipoprotein (LDL) receptor by a reporter assay. TMC-49 A was discovered as an up-regulator obtained from the fermentation bro th of Streptomyces sp. AS1345. The structure of TMC-49A was elucidated to be butyl N-phenethylcarbamate by spectroscopic analyses. This comp ound enhanced the synthesis of LDL receptor in human hepatoma HepG2 ce lls as assessed by a receptor binding assay. Taxonomy of the producing strain is also described.