ANTIMALARIAL ACTIVITY OF RADICICOL, HEPTELIDIC ACID AND OTHER FUNGAL METABOLITES

Authors
TANAKA Y SHIOMI K KAMEI K SUGOHHAGINO M ENOMOTO Y FANG F YAMAGUCHI Y MASUMA R ZHANG CG ZHANG XW OMURA S
Citation
Y. Tanaka et al., ANTIMALARIAL ACTIVITY OF RADICICOL, HEPTELIDIC ACID AND OTHER FUNGAL METABOLITES, Journal of antibiotics, 51(2), 1998, pp. 153-160
Citations number
14
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology,"Biothechnology & Applied Migrobiology
Journal title
Journal of antibiotics → ACNP
ISSN journal
00218820
Volume
51
Issue
2
Year of publication
1998
Pages
153 - 160
Database
ISI
SICI code
0021-8820(1998)51:2<153:AAORHA>2.0.ZU;2-S
Abstract
In the course of our screening program for artemisinin-like antimalari al compounds from microorganisms, seven fungal metabolites such as rad icicol and heptelidic acid were identified as active compounds. Some o f them exhibited antimalarial activity in vitro against the human mala ria parasite Plasmodium falciparum to the extent of approximately 1/10 as potent as artemisinin. Radicicol was moderately active in vivo aga inst Plasmodium berghei in mice.