DECREASED SOLUBLE INTERLEUKIN-6 RECEPTOR IN CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMERS-DISEASE

Authors
HAMPEL H SUNDERLAND T KOTTER HU SCHNEIDER C TEIPEL SJ PADBERG F DUKOFF R LEVY J MOLLER HJ
Citation
H. Hampel et al., DECREASED SOLUBLE INTERLEUKIN-6 RECEPTOR IN CEREBROSPINAL-FLUID OF PATIENTS WITH ALZHEIMERS-DISEASE, Brain research, 780(2), 1998, pp. 356-359
Citations number
23
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
780
Issue
2
Year of publication
1998
Pages
356 - 359
Database
ISI
SICI code
0006-8993(1998)780:2<356:DSIRIC>2.0.ZU;2-O
Abstract
The function of the cytokine interleukin-6 (IL-6) is augmented by solu ble IL-6 receptors (sIL-6R). We investigated cerebrospinal fluid sIL-6 R concentrations in patients with Alzheimer's disease (AD) compared to age-matched healthy subjects and individuals with at least one first degree relative with AD. We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analy sis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology. (C) 1998 Elsevier Science B.V.