THE DOSY EXPERIMENT PROVIDES INSIGHTS INTO THE PROTEGRIN-LIPID INTERACTION

The measure of translational diffusion using PFG NMR has known a renew al of interest with the development of the DOSY experiments. The extra ction of diffusion coefficients from these experiments requires an inv erse Laplace transform. We present here the use of the Maximum Entropy technique to perform this transform, and an application of this metho d to investigate the interaction protegrin-lipid. We show that the ana lysis by DOSY experiments permits to determine some of the interaction features.