THE PRELIMINARY SOLUTION STRUCTURE OF HUMAN P13(MTCP1) AN ONCOGENIC PROTEIN ENCODED BY THE MTCP1 GENE, USING 2D HOMONUCLEAR NMR

Authors
GUIGNARD L YANG YS PADILLA A BOITEAU C STRUB MP HOH F STERN MH ROUMESTAND C
Citation
L. Guignard et al., THE PRELIMINARY SOLUTION STRUCTURE OF HUMAN P13(MTCP1) AN ONCOGENIC PROTEIN ENCODED BY THE MTCP1 GENE, USING 2D HOMONUCLEAR NMR, Journal de chimie physique et de physico-chimie biologique, 95(2), 1998, pp. 454-459
Citations number
11
Categorie Soggetti
Biology,"Chemistry Physical
Journal title
Journal de chimie physique et de physico-chimie biologique → ACNP
Volume
95
Issue
2
Year of publication
1998
Pages
454 - 459
Database
ISI
SICI code
Abstract
The human oncogenic protein p13 is coded by the gene MTCP1 which is ex pressed on mature prolymphocytic leukemias. We investigate its 3D stru cture using 2D homonuclear NMR. The main secondary structure elements found in p13(MTCP1) are antiparallel beta-sheets which fold in an eigh t-stranded orthogonal beta-barrel.