PHARMACOLOGICAL PROFILE OF NICARDIPINE HYDROCHLORIDE IN ANESTHETIZED DOGS WITH ACUTE HEART-FAILURE PART 2 - EFFECT ON MYOCARDIAL-METABOLISM

The effect of nicardipine hydrochloride (NIC. CAS 54527-84-3, Perdipin e(R)) on myocardial metabolism was investigated in an experimental mod el of ischemic acute heart failure (AHF) induced by coronary ligation in anesthetized dogs. The left anterior descending and/or circumflex c oronary ligation decreased coronary sinus blood flow (CBF), maximum ra te of rise of left ventricular pressure (max. dp/dt), cardiac output ( GO) and stroke volume (SV), and increased left ventricular end-diastol ic pressure, indicating the development of AHF. In this ischemic AHF m odel, NIC (3 mu g/kg/min i.v. infusion for 15 min) increased CBF, CO a nd SV, and reduced systemic and coronary artery resistances, resulting in the improvement of AHF. During the effective period, NIC decreased myocardial oxygen consumption and the coronary arterio-venous differe nce of oxygen content, carbon dioxide pressure and pH. At the same tim e, NIC did not decrease the lactate extraction. These results suggest that NIC improves hemodynamics and the balance of myocardium oxygen su pply and demand in dogs with AHF by means of reducing afterload and di lating coronary artery.