EFFECT OF SUBINHIBITORY CONCENTRATIONS OF SOME QUINOLONES ON A STRAINOF SHIGELLA-DYSENTERIAE TYPE-1

Authors
HOSTACKA A KARELOVA E
Citation
A. Hostacka et E. Karelova, EFFECT OF SUBINHIBITORY CONCENTRATIONS OF SOME QUINOLONES ON A STRAINOF SHIGELLA-DYSENTERIAE TYPE-1, Arzneimittel-Forschung, 48(2), 1998, pp. 185-187
Citations number
22
Categorie Soggetti
Pharmacology & Pharmacy","Chemistry Medicinal
Journal title
Arzneimittel-Forschung → ACNP
ISSN journal
00044172
Volume
48
Issue
2
Year of publication
1998
Pages
185 - 187
Database
ISI
SICI code
0004-4172(1998)48:2<185:EOSCOS>2.0.ZU;2-G
Abstract
Sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) r evealed that the outer membrane proteins of a strain of Shigella dysen teriae exposed to four quinolone compounds (ciprofloxacin - CAS 85721- 33-1, ofloxacin - CAS 83380-47-6, pefloxacin - CAS 70458-95-6, and eno xacin - CAS 74011-58-8) at subinhibitory concentrations of 1/4 or 1/8 of the minimal inhibitory concentration (MIG) showed no alterations as compared to the control. Also the hydrophobicity of the cell surface of the test strain was not affected after exposure to subinhibitory co ncentrations of the quinolones.