PEPTIDE EXCRETION IN CELIAC-DISEASE

Background: In celiac disease, the mucosa in the small intestine is da maged. This study was conducted to determine whether the normal peptid e and protein uptake from the put is increased in patients with celiac disease. Methods: The low-molecular-weight peptides were measured in urine from children and adults with untreated celiac disease. A revers ed-phase technique was used. Results: The excretion of peptides increa sed compared with that in an age-and sex-matched reference group. Conc lusions: Celiac patients have hyperpeptiduria. It is possible that som e of these peptides are bioactive and may mediate varying systemic eff ects also found in untreated celiac disease.