COMPARATIVE-STUDY OF THE DIALYZABILITY OF IOBITRIDOL AND IOHEXOL IN THE RAT WITH IMPAIRED RENAL-FUNCTION

Purpose: To assess the dialysability of iobitridol, a comparative stud y with iohexol was conducted in the rat over 4 hours. Material and Met hods: After ligature of the renal Veins and arteries, a group of anima ls was submitted to continuous peritoneal dialysis, while the remainde r were not. Results: In the event of total renal failure, biliary excr etion rose from 0.4 to 9% for iobitridol and from 2 to 16% for iohexol . In the rats submitted to peritoneal dialysis, biliary excretion decr eased to 5% in the iobitridol group and to 13% in the iohexol group. F urther, 18% of the test substances were eliminated in the dialysis liq uid. Conclusions. As their physicochemical characteristics are very si milar, the differences between the biliary excretion levels of these 2 media may be caused by a factor related to their respective molecular conformations.