A FREEZE-DRIED INJECTABLE FORM OF FLURBIPROFEN - DEVELOPMENT AND OPTIMIZATION USING RESPONSE-SURFACE METHODOLOGY

Authors
KAGKADIS KA REKKAS DM DALLAS PP CHOULIS NH
Citation
Ka. Kagkadis et al., A FREEZE-DRIED INJECTABLE FORM OF FLURBIPROFEN - DEVELOPMENT AND OPTIMIZATION USING RESPONSE-SURFACE METHODOLOGY, International journal of pharmaceutics, 161(1), 1998, pp. 87-94
Citations number
8
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
International journal of pharmaceutics → ACNP
ISSN journal
03785173
Volume
161
Issue
1
Year of publication
1998
Pages
87 - 94
Database
ISI
SICI code
0378-5173(1998)161:1<87:AFIFOF>2.0.ZU;2-K
Abstract
In this study a complex of flurbiprofen and 2-hydroxypropyl-beta-cyclo dextrin (2-HP beta CD), was prepared employing a freeze-drying method. The production parameters and the final specifications of this produc t were optimised by using response surface methodology. The results sh ow that the freeze-dried complex meets the requirements for solubility to be considered as a possible injectable form. (C) 1998 Elsevier Sci ence B.V.