ANTIMICROBIAL ACTIVITY OF NOVEL FURANONAPHTHOQUINONE ANALOGS

Authors
NAGATA K HIRAI KI KOYAMA J WADA Y TAMURA T
Citation
K. Nagata et al., ANTIMICROBIAL ACTIVITY OF NOVEL FURANONAPHTHOQUINONE ANALOGS, Antimicrobial agents and chemotherapy, 42(3), 1998, pp. 700-702
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
42
Issue
3
Year of publication
1998
Pages
700 - 702
Database
ISI
SICI code
0066-4804(1998)42:3<700:AAONFA>2.0.ZU;2-D
Abstract
Analogs of furanonaphthoquinone (FNQ) from Tecoma ipe Mart had MICs ra nging from 1.56 to 25 mu g/ml against gram-positive bacteria. FNQ show ed significantly lower MICs against methicillin-resistant Staphylococc us aureus than against methicillin-sensitive S. aureus. FNQ inhibited Helicobacter pylori with an MIC of 0.1 mu g/ml. Fungi, including patho genic species, were sensitive to FNQ with MICs similar to those of amp hotericin B.