K. Umetani et al., 24 HOUR TIME-DOMAIN HEART-RATE-VARIABILITY AND HEART-RATE - RELATIONSTO AGE AND GENDER OVER 9 DECADES, Journal of the American College of Cardiology, 31(3), 1998, pp. 593-601
Objectives. This study sought to define the effects of age and gender
effects on the normal range of time domain heart rate variability (HRV
) over nine decades in healthy subjects. Background. Low HRV is consid
ered an independent marker of mortality risk. However, the age-related
decline in HRV may limit its predictive value, particularly in the el
derly. Delineation of the range of HRV in healthy subjects over the li
fe span is needed. Gender-related differences in HRV also need clarifi
cation. Methods. We determined, according to decade, 24-h heart rate (
HR) and HRV of 260 healthy subjects (10 to 99 years old; 112 male, 148
female) by means of five standard time domain measures: standard devi
ation of all normal sinus RR intervals over 24 h (SDNN), standard devi
ation of the averaged normal sinus RR intervals for all 5-mm segments
(SDANN), mean of the standard deviations of all normal sinus RR interv
als for all 5-min segments (SDNN index), root mean square of successiv
e normal sinus RR interval difference (rMSSD) and the percentage of su
ccessive normal sinus RR intervals >50 ms (pNN50). Results. 1) HRV dec
reased with aging, the pattern of change being measure dependent. HRV
(SDNN and SDANN) decreased only very gradually, reaching 60% of baseli
ne (second-decade values) by the tenth decade. With the SDNN index, HR
V decreased linearly with aging, reaching 46% of baseline by the tenth
decade. Using pNN50 and rMSSD, HRV decreased most rapidly, reaching 2
4% and 47% of baseline, respectively, by the sixth decade and then sta
bilized. 2) Using the SDNN index, rMSSD and pNN50, HRV of subjects >65
years old fell below published cutpoints for increased risk of mortal
ity in 25%, 12% and 4%, respectively. 3) At age <30 years, HRV for all
measures was lower in female than male subjects. Gender differences d
ecreased at age >30 gears and disappeared at age >50 years. 4) HR also
declined with aging but much more slowly. HR at age <50 years was fas
ter in female than in male subjects. Gender differences disappeared th
ereafter. Conclusions. 1) Using all measures, HRV of healthy subjects
declines with aging, with measure-dependent patterns. 2) Using the SDN
N index, rMSSD and pNN50, HRV of healthy subjects, particularly those
>65 years old, may decrease to below levels associated with increased
risk of mortality. 3) Gender influences HRV. Gender differences in HRV
are age and measure dependent. 4) Age and gender also affect heart ra
te. (C) 1998 by the American College of Cardiology.