THE SARCO(ENDO)PLASMIC RETICULUM CA2-ATPASES IN THE CARDIOVASCULAR-SYSTEM DURING GROWTH AND PROLIFERATION()

The sarco(endo)plasmic reticulum Ca2+-ATPase is present in all cell ty pes and is essential in restoring a low cytosolic Ca2+ concentration a fter cell activation. In the past years, six different isoforms encode d by three genes have been identified by cDNA cloning. Some of these i soforms are expressed in the cardiovascular system, and their expressi on is regulated during proliferation that occurs during ontogenic deve lopment as well as in pathological cell growth. This article reviews t he new features concerning isoform diversity of the sarco(endo)plasmic reticulum Ca2+-ATPase and modulation of expression of these isoforms in cardiac and vascular cells. (C) 1998, Elsevier Science Inc.