Evaluation of the fertilizing potential of sperm is an important proce
dure in in vitro fertilization and embryo transfer (IVF-ET) clinic, in
order to avoid performing invalid conventional IVF-ET or unnecessary
intracytoplasmic sperm injection (ICSI). However, none of the standard
semen parameters are reliable indices in predicting IVF outcome. The
test examining sperm-zona interaction is the best present method, thou
gh the short supply of the human zona component should be solved. IVF-
ET treatment is useful for pregnancy in women having sperm immobilizin
g antibodies because it avoids exposing sperms to antibodies that bloc
k fertilization. ICSI should be used in immunologically infertile men
diagnosed by specific method to demonstrate the in vivo exposure of sp
erms to antisperm autoantibodies that block fertilization.