EFFECT OF ANTIBIOTIC-THERAPY IN ASTHENOZOOSPERMIC MEN ASSOCIATED WITHINCREASED AGGLUTINATION AND MINIMAL LEUKOSPERMIA

Thirteen patients with asthenozoospermia and semen analysis suggestive of infection were studied and divided at random into 2 groups accordi ng to the antibiotic treatment they received: (I) ciprofloxacine 250 m g every 12 hours by 14 days per os (n = 7) and (II) trimethoprim 160 m g and sulfamethoxazole 800 mg every 12 hours by 14 days per os (n = 6) . Their couples received the same treatment. Changes in sperm density, morphology, viability, motility, agglutination, pH, and presence of l eukocytes were analyzed before and after treatment. The average of mor phologically normal sperms significantly decreased after treatment in the ciprofloxacine group; sperm with grade III motility increased in t he trimethoprim-sulfamethoxazole group, but without statistical signif icance. With these preliminary results, it can be concluded that antib iotic administration modifies some of the spermatic parameters, partic ularly motility and morphology, in patients whose semen analysis param eters suggested infection.