MOLSIDOMINE AND ISOSORBIDE DINITRATE - A COMPARATIVE TRIAL OF TOLERANCE IN LONG-TERM INTAKE BY IHD PATIENTS WITH STABLE ANGINA OF EFFORT

Potential tolerance to isosorbide dinitrate (ID) and molsidomine (M) w as studied in 18 ischemic heart disease (IHD) patients with stable ang ina of effort entered in a double blind cross-over trial. Each drug wa s administered for 3 weeks 4 times a day in individual effective dose. Single doses of ID and M were similar by effectiveness, but after 3 w eeks of regular intake their efficacy fell, ID becoming less potent th an M. For ID, tolerance after long-term intake manifested in 7 out of 18 patients, for M - in 5 out of 18. Complete tolerance was registered in 3 of 18 and 1 of 18 patients, respectively. Thus, tolerance is pos sible for the two drugs, but for M it is less pronounced.