Antibiotic resistance develops among bacterial species just as Darwin
might have predicted - that is, through natural selection. Because bac
terial species can share DNA by a variety of mechanisms, and because s
ome of these microbes are inherently resistant to one or more major an
tibiotics, we should not be surprised that clinically important specie
s of bacteria can become resistant to commonly used antibiotics by cha
nce alone. The rapid increase in the percentage of strains resistant t
o one or more antibiotics, especially broad-spectrum agents, may be th
e result of increased use of such compounds.