Ac. Nyquist et al., ANTIBIOTIC PRESCRIBING FOR CHILDREN WITH COLDS, UPPER RESPIRATORY-TRACT INFECTIONS, AND BRONCHITIS, JAMA, the journal of the American Medical Association, 279(11), 1998, pp. 875-877
Context.-The spread of antibiotic-resistant bacteria is associated wit
h antibiotic use. Children receive a significant proportion of the ant
ibiotics prescribed each year and represent an important target group
for efforts aimed at reducing unnecessary antibiotic use. Objective.-T
o evaluate antibiotic-prescribing practices for children younger than
18 years who had received a diagnosis of cold, upper respiratory tract
infection (URI), or bronchitis in the United States. Design.-Represen
tative national survey of practicing physicians participating in the N
ational Ambulatory Medical Care Survey conducted in 1992 with a respon
se rate of 73%. Setting.-Office-based physician practices. Participant
s.-Physicians completing patient record forms for patients younger tha
n 18 years. Main Outcome Measures.-Principal diagnoses and antibiotic
prescriptions. Results.-A total of 531 pediatric office visits were re
corded that included a principal diagnosis of cold, URI, or bronchitis
, Antibiotics were prescribed to 44% of patients with common colds, 46
% with URIs, and 75% with bronchitis. Extrapolating to the United Stat
es, 6.5 million prescriptions (12% of all prescriptions for children)
were written for children diagnosed as having a URI or nasopharyngitis
(common cold), and 4.7 million (9% of all prescriptions for children)
were written for children diagnosed as having bronchitis. After contr
olling for confounding factors, antibiotics were prescribed more often
for children aged 5 to 11 years than for younger children (odds ratio
[OR], 1.94; 95% confidence interval [CI], 1.13-3.33) and rates were l
ower for pediatricians than for nonpediatricians (OR, 0.57; 95% CI, 0.
35-0.92), Children aged 0 to 4 years received 53% of all antibiotic pr
escriptions, and otitis media was the most frequent diagnosis for whic
h antibiotics were prescribed (30% of all prescriptions). Conclusions.
-Antibiotic prescribing for children diagnosed as having colds, URIs,
and bronchitis, conditions that typically do not benefit from antibiot
ics, represents a substantial proportion of total antibiotic prescript
ions to children in the United States each year.