IMMUNOADJUVANT EFFECT OF INACTIVATED CRYPTOCOCCUS-NEOFORMANS

Cryptococcus neoformans disseminated into the central nervous system ( CNS) of intraperitoneally inoculated adult ICR mice, but did not poten tiate penetration of concurrently given Bhanja virus (Bunyaviridae) in to the CNS. Likewise, Bhanja virus infection did not affect significan tly the course of murine cryptococcosis. However, formalin-killed C. n eoformans cells non-specifically increased production of antibodies ag ainst the virus infection in the animals.