CONTROL OF INFLAMMATORY DAMAGE BY ANTI-LFA-1 - INCREASE SUCCESS OF MYOBLAST TRANSPLANTATION

Myoblast transplantation is a potential treatment for Duchenne Muscula r Dystrophy. This article confirms by experiments in mice that one pro blem that has limited the success of clinical trials of this procedure is a rapid (within 3 days) inflammatory reaction which kills most of the injected myoblasts, The death of the transplanted myoblasts can be prevented by treating the host with a mAb against LFA-1. This led to a 27-fold increase in the number of muscle fibers expressing a reporte r gene present in the donor myoblasts when the host is also adequately immunosuppressed with FK506, Therefore, both the nonspecific inflamma tory reaction and the specific immune response should be adequately co ntrolled following myoblast transplantation. (C) 1997 Elsevier Science Inc.