ASSOCIATION BETWEEN ASTHMA AND AN INTRAGENIC VARIANT OF CC16 ON CHROMOSOME 11Q13

The beta subunit of high affinity immunoglobulin E (IgE) receptor (Fc epsilon RI beta) and the Clara cell derived inflammatory molecule, CC1 6 have been cited as candidate genes for atopic asthma on chromosome 1 1q13. A genetic association study was performed with an intragenic mic rosatellite repeat of CC16 gene on chromosome 11q12-13 in relation to atopic and non-atopic asthma, Whereas variants of Fc epsilon RI beta a t chromosome 11q13 show association with atopy and asthma. no signific ant association was found between asthma and CC16 genotypes irrespecti ve of atopic status, These data support the candidacy of Fc epsilon RI beta rather than CC16 for the atopic asthma locus on chromosome 11q.