SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW INDOLYLTHIAZINONE DERIVATIVES

Authors
DZURILLA M KUTSCHY P TEWARI JP RUZINSKY M SENVICKY S KOVACIK V
Citation
M. Dzurilla et al., SYNTHESIS AND ANTIFUNGAL ACTIVITY OF NEW INDOLYLTHIAZINONE DERIVATIVES, Collection of Czechoslovak Chemical Communications, 63(1), 1998, pp. 94-102
Citations number
14
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
63
Issue
1
Year of publication
1998
Pages
94 - 102
Database
ISI
SICI code
0010-0765(1998)63:1<94:SAAAON>2.0.ZU;2-R
Abstract
New 6-(indol-3-yl)-5.6-dihydro-4H-1,3-thiazin-4-one derivatives were p repared by boron trifluoride catalyzed intramolecular cyclization of N '-substituted N-[3-(indol-3-yl)propenoyl]thioureas and by the reaction of 3-(indol-3-yl)propenoyl isothiocyanate with sodium hydrogensulfide . Antifungal activity of the prepared compounds was studied using the fungi Alternaria brassicae and Alternaria brassicicola.