2,4-DIHYDROXYACETOPHENONE DERIVATIVES AS ANTILEUKOTRIENICS WITH A MULTIPLE ACTIVITY MECHANISM

Authors
KUCHAR M CULIKOVA K PANAJOTOVOVA V BRUNOVA B JANDERA A KMONICEK V
Citation
M. Kuchar et al., 2,4-DIHYDROXYACETOPHENONE DERIVATIVES AS ANTILEUKOTRIENICS WITH A MULTIPLE ACTIVITY MECHANISM, Collection of Czechoslovak Chemical Communications, 63(1), 1998, pp. 103-114
Citations number
28
Categorie Soggetti
Chemistry
Journal title
Collection of Czechoslovak Chemical Communications → ACNP
ISSN journal
00100765
Volume
63
Issue
1
Year of publication
1998
Pages
103 - 114
Database
ISI
SICI code
0010-0765(1998)63:1<103:2DAAWA>2.0.ZU;2-Q
Abstract
A series of 2,4-dihydroxy-3-propylacetophenone derivatives containing alkylthiobenzoic or arylacetic acid moiety was prepared. The antileuko trienic activity of the substances was assessed in terms of inhibition of the biosynthesis of LTB4 and bonding to LTB4 and LTD4 receptors. S ome of the substances were found to exert a complex antileukotrienic e ffect in all of the three tests. The compounds also displayed an antii nflammatory effect, as manifested by a significant inhibition of LTD4- induced bronchospasm.