MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A RABBIT RENAL ORGANICCATION TRANSPORTER

Authors
TERASHITA S DRESSER MJ ZHANG L GRAY AT YOST SC GIACOMINI KM
Citation
S. Terashita et al., MOLECULAR-CLONING AND FUNCTIONAL EXPRESSION OF A RABBIT RENAL ORGANICCATION TRANSPORTER, Biochimica et biophysica acta. Biomembranes, 1369(1), 1998, pp. 1-6
Citations number
23
Categorie Soggetti
Biology,Biophysics
Journal title
Biochimica et biophysica acta. Biomembranes → ACNP
ISSN journal
00052736
Volume
1369
Issue
1
Year of publication
1998
Pages
1 - 6
Database
ISI
SICI code
0005-2736(1998)1369:1<1:MAFEOA>2.0.ZU;2-M
Abstract
A cDNA encoding an organic cation transporter (rbOCT1) was isolated fr om rabbit kidney. The cDNA encodes a 554 amino acid protein that is hi ghly homologous to other mammalian organic cation transporters. rbOCT1 mediated H-3-1-methyl-4-phenylpyridinium (H-3-MPP+) transport in Xeno pus laevis oocytes was saturable, sensitive to membrane potential, and inhibited by various organic cations. rbOCT1 mRNA transcripts are exp ressed in the kidney, liver, and intestine. (C) 1998 Elsevier Science B.V.