APOE POLYMORPHISM IN POLISH PATIENTS WITH ALZHEIMERS-DISEASE

Alzheimer's disease is a genetically heterogeneous disorder of CNS. Th e presence of APOE-epsilon 4 allele is known to increase the risk of e arly and late onset sporadic and late onset familial forms of AD. In v arious Western European countries, USA, Canada, Japan and Australia th e allelic frequency ranges between 0.1-0.18 in controls, and between 0 .24-0.52 in AD patients. In the present study on Polish population, we analyzed the frequency of APOE-epsilon 4 allele in persons with Alzhe imer's disease (AD). APOE genotypes were determined in 30 mild to mode rate AD (83%) and mixed dementia (MIX, 17%), as well as in 11 nondemen ted first-degree relatives of AD (NDR), recruited from AD patient regi stry in Warsaw. Among the AD and MIX patients the APOE-epsilon 4, epsi lon 3, epsilon 2 allele frequency was 0.333, 0.65 and 0.017 respective ly.